Hydroxyapatite
Hydroxyapatite
What is "HAP"?
Hydroxyapatite (HAP) [Ca₁₀(PO₄)₆(OH)₂] is a naturally occurring form of calcium phosphate that makes up approximately 60% of human bones, 97% of tooth enamel, and 70% of dentin. Even synthetic hydroxyapatite is a highly biocompatible and safe biomaterial that integrates well with the human body. It can also be engineered to exhibit a variety of properties depending on the synthesis method.
Thanks to its high level of safety, hydroxyapatite is used in a wide range of applications, including industrial raw materials, food additives, cosmetic ingredients, and even biomedical uses such as artificial bone.
Key Features
Hydroxyapatite is the main component of bones and teeth in mammals.
As a food additive, it is a calcium phosphate compound known for its excellent bioavailability in the human body.
When consumed, it helps to strengthen bones.
It disperses easily in gum bases, gelatin, pectin, and other gelling agents.
Unlike calcium carbonate, it does not cause foaming when dissolved in stomach acid, eliminating discomfort after ingestion.
It remains stable even after both low-temperature and high-temperature sterilization processes.
Product Lineup
Sangi offers a wide range of hydroxyapatite grades tailored to customer needs.
| Product Name | Applications |
|---|---|
| Aparin ® * | Cosmetic ingredients |
| Apamed ® | High-purity products for biomedical use such as artificial bone and dental implants |
| Apacal ® | Government-approved food additive (Japan) |
| Apagen ® | Inorganic fillers and industrial raw materials |
* Aparin complies with The Japanese Standards of Quasi-Drug Ingredients (2021).
Product Development
For over 30 years, Sangi has been researching hydroxyapatite, establishing unique technologies and distinctive manufacturing methods, and its science continues to evolve to this day.
Our Chemical Products team is dedicated to creating products that meet customer needs by precisely controlling particle shapes (such as spherical, plate-like, and physalis-like), particle size, surface area, and more.
SEM Images of HAP particles (Examples: Spherical, Plate-like, Physalis-like)