What is Hydroxyapatite?

60% of human bone, 97% of tooth enamel and 70% of dentin are made of the natural calcium phosphate hydroxyapatite, Ca10(PO4)6(OH)2, also known as "HAP." Even in its synthetic form,  hydroxyapatite is a safe material with strong affinity for the human body. Moreover, it can have various characteristics according to the method of synthesis.


Due to its high level of safety as a biomaterial, hydroxyapatite is used widely in industrial, cosmetic and medical applications, in particular for use in the human body, for example as an additive in foods or a raw material in drug manufacture, dental implants or artificial bones.


  • Hydroxyapatite is the main component of mammalian bones and teeth.
  • It is an authorized food additive, offering an excellent source of calcium and phosphorus, easily absorbable by the human body.
  • With daily consumption, it can improve bone density.
  • It disperses easily in a gum base, gelatin, pectin and other gelling agents.
  • Unlike calcium carbonate, it does not foam when dissolved by stomach acids, so there is no discomfort after eating.
  • Changes will not occur even in the case of low temperature or high temperature sterilization.

Product Line-up





Cosmetics additive

Oil and protein (e.g. keratin) removal


Pharmaceutical excipients, bulking agents, or biomaterials such as artificial bones and tooth roots (for research)

Promotion of bone regeneration, coating to support bio acceptability of implant materials, indwelling catheters etc.


Approved food additive

Easily digestible calcium and phosphorous source


Industrial raw materials, such as inorganic fillers

White pigment, chromatography adsorption agent

* APARIN is in conformity with Japan's Quasi-Drug Raw Material Standard 2006

Other types can be prepared, according to customers' needs.


The Experienced Pioneer . . . Sangi's Hydroxyapatite Chemical Products

Sangi Co., Ltd. - 'The Apatite Company' - specializes in development and sale of products based on the calcium phosphate compound hydroxyapatite, the natural component of teeth and bone. On a hint from a US National Aeronautics and Space Administration (NASA) patent acquired shortly after its establishment in 1974, Sangi developed the world's first hydroxyapatite remineralizing toothpaste, Apadent, in 1978, marketing it in Japan from as early as 1980. Sangi's ingredient was officially recognized by the Japanese government as an anti-caries agent in 1993, under the name of Medical Hydroxyapatite, and was reduced from 3-figure to 2-figure nano-scale for use in even higher performance toothpastes from 2004. Sangi's top-selling brand Apagard, marketed since 1985, and now increasingly available overseas, continues to hold top share in Japan's high end, high performance natural whitening toothpaste market sector.

With over 40 years experience in the hydroxyapatite field, Sangi also offers, in addition to its oral care portfolio, different hydroxyapatites and antimicrobial agents for manufacturing use, based on its accumulated know-how in the development and applications of this highly versatile material.
The chemical product team aims to create products that respond to customer's requests by controlling the particle shape (spherical, plate, crown etc.), particle size, surface area, etc.