Silver-containing Inorganic
Antibacterial Agents
Safety, Licensing and Regulatory Compliance
Safety
Proper handling of antibacterial agents requires a clear understanding of their potential impact on human health and the environment. Therefore, antibacterial agents used in product development must demonstrate excellent safety profiles.
Apacider AK and AW have undergone various safety evaluations and have been confirmed to be highly safe, as shown below.
| Safety Evaluation Items | Evaluation Results | |
|---|---|---|
| AK | AW | |
| Acute Oral Toxicity | >5,000mg/kg | >5,000mg/kg |
| Primary Skin Irritation | Mild irritation (P.I.I.: 0.13) | Mild irritation (P.I.I.: 0.04) |
| Skin Sensitization | Negative | Negative |
| Mutagenicity | Negative | Negative |
The value shown for acute oral toxicity represents the dose required to cause death in 50% of male and female rats (LD50) when the substance is administered orally.
Compared to sodium chloride, which generally has an LD50 value of over 3,000 mg/kg, Apacider AK and AW demonstrate significantly higher safety.
Licensing and Regulatory Compliance
EPA (U.S. Environmental Protection Agency)
The EPA is a U.S. government agency dedicated to protecting and preserving human health and the environment, including air, water, and soil. Its efforts focus on preventing the spread of harmful chemicals that contribute to air and water pollution, food contamination from pesticide residues, and overall environmental degradation.
Both Apacider AK and AW have passed the EPA’s rigorous safety evaluations. They are approved for use in a wide range of applications, including resin films and sheets, paints, processed paper products (excluding food wrapping paper and items in direct contact with food), fibers, textiles, non-woven fabrics, adhesives, and flexible tubing.
EPA Registration Number
| Product | Registration Number |
|---|---|
| AK | 68317-1 |
| AW | 68317-2 |
Scope of EPA Registration
| Application | Materials |
|---|---|
| Films | Polyethylene (PE), Polypropylene (PP), Polyvinyl chloride (PVC), Polyurethane + Polyester (URE + PET) (excluding food packaging materials and water supply pipes) |
| Paints (Water-Based and Solvent-Based) | For interior and furniture use |
| Textiles | Polyethylene (PE), Polyester (PET), Nylon (PA), Acrylic (PMMA), Polyurethane + Polyester (URE + PET) |
| Sheets | Melamine (MF), Epoxy (EP), Phenolic (PF), Polycarbonate (PC), Polyurethane (URE), Acrylic (PMMA), Acrylonitrile-Butadiene-Styrene (ABS), Polyvinyl acetate (PVA), Polyvinyl chloride (PVC), Polyester (PET), Styrene-butadiene rubber (SBR) |
| Processed Paper | Cellulose, reinforced paper, etc. |
| Fabrics, Woven/Knitted Textiles, and Nonwoven Fabrics (Surface-Finished or Compounded) | Polypropylene (PP), Polyethylene (PE), Polyester (PET), Polyvinyl Chloride (PVC), Polyester + Nylon (PET + PA) |
| Flexible Tubing | Silicone resin, Polyvinyl chloride (PVC), Polyethylene (PE) (excluding items intended for food contact) |
| Adhesives | Natural rubber, synthetic rubber (excluding items intended for food contact) |
SIAA (Society of Industrial Technology for Antibacterial Articles)
SIAA is an organization comprising manufacturers of antibacterial agents and antibacterially treated products, as well as antibacterial testing laboratories.
Apacider AW, AK, and Z are registered with SIAA.
We have submitted minimum bactericidal concentration data, safety test results, and
Safety Data Sheets (SDS) for Apacider to SIAA, and they have met the organization’s
strict standards for antibacterial efficacy and safety.
SIAA Registered Product Names and Codes
| Product Name | Registration Code |
|---|---|
| AW | JP0111013A0001J |
| AK | JP0111013A0002K |
| Z | JP0111013A0003L |
Information on registered product names and codes is available on the official SIAA website and is publicly accessible to consumers. SIAA member companies are permitted to use the SIAA mark on antibacterial agents and antibacterially treated products in accordance with the organization’s guidelines. The mark signifies verified antibacterial efficacy and safety. Products bearing the SIAA mark are recognized as meeting high quality and safety standards, not only in Japan but also across Asia, Europe, and North America.