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Silver based inorganic
antibacterial agent "APACIDER"

What is "APACIDER"?

"APACIDER" is a unique antibacterial material with metallic silver supported on calcium phosphate, and it has various advantages compared with organic antibacterial agent and silver ion antibacterial agent.

Product Line

Sangi prepares various grades according to customer's application. 

GRADE

USE

AW

Industrial raw materials (general purpose type)

AK

Industrial raw material (fine particle type)

Z

Industrial raw material (fine particle type) *

AW-N

Cosmetics, toiletry products etc. (including quasi-drugs)

Antiseptic substitutes for cosmetics (general purpose type)

C

Cosmetic products, toiletry products etc. (including quasi-drugs) Preservative replacement (fine particle type)

* Z will be zinc antibacterial agent only.

 

Characteristic

  • Broad antibacterial spectrum
  • Avoid using preservatives
  • High sustainability of antibacterial action, keep product long and clean
  • There is no coloring, discoloration, smell change, etc., it is possible to keep beauty of product state
  • It has almost no toxicity and skin irritation, and it can be used for cosmetics, toiletry products, etc.
  • It has high heat resistance and stability, it can be applied to a wide range of materials such as synthetic resin and paper
  • It has been approved by EPA (US Environmental Protection Agency), and it is possible to export processed products

What is 'ANTIBACTERIAL'?

Definition of fungus control

"Antibacterial" in antimicrobial processed products that are currently on sale is "a state that suppresses the growth of bacteria (including fungi) on the surface of products." It is a function different from "sterilization" which kills microorganisms and "bacteria removal" which removes microorganisms.
Below is a summary of differences in antibacterial, sterilization, sterilization, disinfection, and eradication.

 

THE TERM

DEFINITION

Antibacterial

Condition that suppresses bacterial growth on the surface of products 1) ≒ bacteria 2)

Sterilization

Kill or remove all microorganisms in the substance 3)

Sterilization

Kill some or most microorganisms in the substance 4)

Disinfection

A treatment method used to reduce the number of surviving microorganisms, not necessarily to kill or remove all microorganisms 5)

Removing bacteria

Reduce the effective amount of the number of bacteria (viable count) that can grow from the object.  However, fungi such as mold and yeast are not included 6)

 

[Source]
1) JIS Z 2801, ISO22196
2) JIS L 1902
3) 16th revision Japanese Pharmacopoeia General test method P128
4) Soap Detergent Association websiteJapan

5) The 16th revision Japanese Pharmacopoeia Microbial disinfection method P2041

6) Japan Soap and Detergent Industry Association

General "antibacterial mechanism" hypothesis

Antibacterial agents have different effects on microorganisms depending on their chemical structure, but various theories have been proposed regarding the antibacterial mechanism. A typical one is any combination of the following.

 

Antibacterial substances. . .

1. Adsorbs on the surface of microorganisms and inhibits various functions of cell membranes

2. Destroy cell membranes and cell walls to make holes and leak intracellular material (see below)

3. Invade into cells and directly organize intracellular substances or inhibit their function

4). Inhibits respiration by destabilizing the respiratory enzymes that are retained in the cell membrane

5). Inhibits cellular DNA and RNA gene synthesis or inhibits transcriptase

(Inhibits the synthesis of various proteins in cells)

6). Other effects such as sterilization by hydroxy radicals created by photoexcitation

 

[Source] Antibacterial technology and market trends 2016 P176-177 (CMC Publishing)

The above figure is an example of the mechanism of a general antibacterial agent. Antibacterial substances have an antibacterial effect by destroying cell membranes and cell walls, making holes and killing microorganisms.