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Silver based inorganic
antibacterial agent "APACIDER"

What is "APACIDER"?

"APACIDER" is a unique antibacterial material with metallic silver supported on calcium phosphate, and it has various advantages compared with organic antibacterial agent and silver ion antibacterial agent.

Product Line-up

GRADE

USE

AW

Industrial raw materials (general purpose type)

AK

Industrial raw material (fine particle type)

Z

Industrial raw material (fine particle type) *

AW-N

Cosmetics, toiletry products etc. (including quasi-drugs)

Antiseptic substitutes for cosmetics (general purpose type)

C

Cosmetic products (fine particle type)

Preservatives replacement in toiletry products etc. (including quasi-drugs)

* The antimicrobial agent in this case is zinc rather than silver.

 

Product Line-up

  • Broad antibacterial spectrum
  • Removes the need to use preservatives
  • Highly sustainable antimicrobial action, protecting the end-product over a long time period
  • Causes no staining, discoloration or change of smell in the end-product, keeping it in its original state over time
  • Non-toxic, non-irritant to the skin, and can be used in cosmetics, toiletry products, etc.
  • Has high heat resistance and stability, and can be applied to a wide range of materials such as synthetic resin and paper
  • Approved by the EPA (US Environmental Protection Agency), facilitating export of processed end-products

What is 'Antimicrobial'?

Definition of microbial control

The definition of "antimicrobial" in the case of antimicrobially processed end-products currently on sale is "in a condition that suppresses the growth of bacteria (including fungi) on the surface of the products." This is a different function from "sterilization," in which microorganisms are killed, or "eradication," in which they are simply removed. The chart below summarizes the differences between the various mechanisms used to control microbes.

TERM

DEFINITION

Antimicrobial

Condition that suppresses growth of microbes on the surface of products 1)

Sterilization

Killing or removal of all microorganisms in the substance 2)

Pasteurization

Killing of some or most microorganisms in the substance 3)

Disinfection

Treatment to reduce the number of surviving microorganisms, not necessarily to kill or remove all microorganisms 4)

Eradication

Reduction of the effective number of bacteria (viable count) that can grow from the object. (Fungi such as yeast and mold not included) 4)

 

[Source]
1) JIS Z 2801, ISO22196, JIS L 1902
2) Japanese Pharmacopoeia 16th revision, General Test Method, p128
3) Japan Soap & Detergent Industry Association website
4) Japanese Pharmacopoeia 16the revision, Microbial Disinfection Method, p2041

General "Antimicrobial Mechanism" Hypothesis

Antimicrobial agents have different effects on microorganisms, depending on their chemical structure, and various theories have been proposed regarding their antimicrobial mechanism. Typical theories are any combination of the following.

 

An antimicrobial is a substance which

1. Attaches to the surface of microorganisms and inhibits various functions of their cell membrane

2. Damages and breaks cell membranes and walls, causing leakage of intracellular material (see

  diagram below)

3. Invades cells and disorganizes intracellular components or inhibits their function

4. Inhibits respiration by destabilizing respiratory enzymes in the cell membrane

5. Inhibits cellular DNA and RNA gene synthesis or transcription, thus inhibiting the synthesis of

  various proteins in cells

6. Has other effects, such as sterilization via hydroxy radicals created by photoexcitation

 

Source: Antimicrobial Technology and Market Trends 2016 pp176-177 (CMC Publishing)

The above figure is an example of the mechanism of a general antibacterial agent. Antibacterial substances have an antibacterial effect by destroying cell membranes and cell walls, making holes and killing microorganisms.