In recent years, interest in and demand for hypoallergenic and hypoallergenic cosmetics has increased due to an increase in skin problems caused by cosmetics. For this reason, cosmetic products such as fragrance-free, color-free, paraben-free, non-alcohol, and former labeling ingredients ¹⁾ are notable for product labels. A typical example is the preservative paraben, which is an old label component that may cause skin problems. The effect of the human body is attracting attention in the EU due to the action of endocrine disruptors (commonly known as environmental hormones) ²⁾ .

However, the role of preservatives is important. This is because if cosmetic contamination and growth occur in cosmetics, it will cause changes such as breakage, discoloration, and odor. As a result, not only the commercial value is lost, but the components decomposed by microorganisms may cause dermatitis.

Therefore, preservatives and bactericides are included in cosmetics as a measure against microbial contamination.
Apasider is an inorganic antibacterial agent in which metallic silver is supported on calcium phosphate, typified by hydroxyapatite, and it is required for antiseptics. It is effective at low concentrations, has a wide antibacterial spectrum, and is highly safe. Each condition is provided.

[Source]
1) August 8, 1967 The former Ministry of Health, Labor and Welfare Notification No. 321 What is the old labeling ingredient Until the former Pharmaceutical Affairs Law was amended (April 1, 2001), there was a risk of rarely causing skin problems such as allergies. It was obliged to display only specific ingredients (103 kinds including fragrances).

Currently, cosmetic ingredients must be labeled as a general rule based on the request of the Ministry of Health, Labor and Welfare (March 6, 2001, Ministry of Health, Labor and Welfare, Department of Pharmacy Examination Management Section, Ministry of Health, Labor and Welfare, Department of Pharmacy Monitoring Guidance and Notification of Drug Administration Section) .

2) Commission Regulation (EU) No 1004/2014 of 18 September 2014 amending Annex V to Regulation (EC) No 1223/2009 of the European Parliament and of the Council on Cosmetic Products

1) Wide antibacterial spectrum
2) High safety
3) Low antibacterial effect
4) Difficult to change product properties
5) Hard to cause coloration, fading and discoloration that impair the appearance of the product *
6) Long lasting antibacterial effect
7) Heat resistant and stable over a wide temperature range

* Combined with the acidic components of chelating agents (EDTA-2Na) and pH adjusters (hydrochloric acid, etc.), apasiders AW-N and C, or sulfur-containing amino acids (keratin, cysteine, etc.) and their derivatives (hydrolyzed keratin, Discoloration may occur when sulfur compounds are added.